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US Patent, "Quantitative Lipidomic Analysis, Methods and Uses Thereof"
Publication number: 20250180508
Abstract: This disclosure relates to the field of lipidomics, and in particular, to a novel derivatization strategy for quantitative lipid methylation and uses thereof. Further, this disclosure relates to use of phospholipid biomarkers for assessing and monitoring Omega-3 Index (O3I), including methods and uses thereof.
Type: Application
Filed: December 2, 2024
Publication date: June 5, 2025
Inventors: Philip Britz-McKibbin, Ritchie Ly
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US Patent, "Method of Diagnosing and Treatment Monitoring of Crohn's Disease and Ulcerative Colitis"
Publication number: 20230015257
Abstract: Methods of diagnosing Crohn’s disease and ulcerative colitis in subjects is provided based on the determination of metabolites in urine samples, such as serine, hypoxanthine, kynurenine, threonine, dimethylglycine, tryptophan, indoxylsul-fate, phenylacetylglutamine, sialic acid, 5-hydroxy-6-indolyl-o-sulfate, 5-(?-carboxybutyl) homocysteine, and/or an anion having m/ z:RMT:polarity of 345.1553:0.770:n, or determination of metabolites in stool samples, such as ketodeoxycholic acid, cholic acid, choline, tryptophan, trimethyllysine, serine, butyric acid, lactic acid, hypoxanthine and/or guanine.
Type: Application
Filed: December 13, 2020
Publication date: January 19, 2023
Inventors: Philip Britz-McKibbin, Nikhil Pai
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US Patent, "Metabolite panel for improved screening and diagnostic testing of cystic fibrosis"
Patent number: 10768183
Abstract: A method of diagnosing cystic fibrosis in a human subject is provided. The method includes the steps of: i) determining in a biological sample from the subject the level of one or more metabolic biomarkers; ii) comparing the level of the biomarker to a control level and determining the difference between the biomarker level and the control level; and iii) determining that the subject has cystic fibrosis or a related disorder when the difference in the level of the biomarker in the sample is statistically different from the control level.
Type: Grant
Filed: November 25, 2016
Date of Patent: September 8, 2020
Assignee: McMaster University
Inventor: Philip Britz-McKibbin
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US Patent, "Allosteric activators for treatment of phenylketonuria"
Patent number: 10426751
Abstract: A method of restoring activity in phenylalanine hydroxylase is provided. The method comprises exposing the phenylalanine hydroxylase to shikimic acid, a functionally equivalent analog thereof, a pharmaceutically acceptable salt of shikimic acid or analog thereof, or combinations thereof.
Type: Grant
Filed: January 8, 2016
Date of Patent: October 1, 2019
Assignee: McMaster University
Inventor: Philip Britz-McKibbin
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US Patent, "Methods for Iodide Determination"
Patent number: 10234421
Abstract: The present application is directed to the use of electrophoresis with UV detection in the determination of iodine nutritional status in human biological specimens, specifically for monitoring iodine deficiency/inadequacy in large-scale epidemiological studies. In particular, the present application is directed to a method for determining iodide and iodide uptake inhibitors in a human biological sample when using sample self-stacking with capillary electrophoresis and UV detection.
Type: Grant
Filed: September 30, 2016
Date of Patent: March 19, 2019
Assignee: McMaster University
Inventor: Philip Britz-McKibbin
- US Patent,“Multi-segment Injection-Capillary Electrophoresis-Mass Spectrometry: A Multiplexed Screening Platform and Data Workflow for Chemical Analysis”
Patent number: 10054566
Abstract: Various embodiments illustrating a multiplexed method for high throughput screening of ions in biological samples within a single capillary when using capillary electrophoresis mass spectrometry (CE-MS) are illustrated. The method includes sequential injection of multiple sample segments in series within a single capillary, the sample segments being separated by a spacer plug of buffer, and multiplexed analysis of the sample segments simultaneously within a single capillary electrophoresis (CE) run. The method also includes application of voltage to the single capillary subsequent to sequential injection and zonal separation of polar metabolites within each sample segment by CE such that each analyte zone migrates within its characteristic electrophoretic mobility offset in time by the spacer.
Type: Grant
Filed: October 14, 2016
Date of Patent: August 21, 2018
Assignee: McMaster University
Inventor: Philip Britz-McKibbin
