Publications

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2019

Saoi, M, Percival, M, Nemr, C, Li, A, Gibala, M, and Britz-McKibbin, P, 2019. "Characterization of the Human Skeletal Muscle Metabolome for Elucidating the Mechanisms of Bicarbonate Ingestion on Strenuous Interval Exercise". Analytical Chemistry, 91(7), 4709-4718 View Abstract

Shanmuganathan, M, Kroezen, Z, Macklai, S, and Britz-McKibbin, P, 2019. "Comprehensive Surveillance of Drugs of Abuse ". GIT Laboratory Journal View Abstract

Saoi, M, Sasaki, K, Sagawa, H, Abe, K, Kogiso, T, Tokushige, K, Hashimoto, E, Ohashi, Y, and Britz-McKibbin, P, 2019. "High Throughput Screening of Serum γ-Glutamyl Dipeptides for Risk Assessment of Nonalcoholic Steatohepatitis with Impaired Glutathione Salvage Pathway". Journal of Proteome Research View Abstract

Shanmuganathan, M, Macklai, S, Barrenas, C, Kroezen, Z, Kim, M, Zizek, W, Lee, H, and Britz-McKibbin, P, 2019. "High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-capillary Electrophoresis Mass Spectrometry". Journal of Visualized Experiments, 146(e58986) View Abstract

Saoi, M, Li, A, McGlory, C, Stokes, T, von Allmen, M, Phillips, S, and Britz-McKibbin, P, 2019. "Metabolic Perturbations from Step Reduction in Older Persons at Risk for Sarcopenia: Plasma Biomarkers of Abrupt Changes in Physical Activity ". Metabolites, 9(7) View Abstract

Wellington, N, Shanmuganathan, M, de Souza, R, Zulyniak, M, Azab, S, Bloomfield, J, Mell, A, Ly, R, Desai, D, Anand, S, and Britz-McKibbin, P, 2019. "Metabolic Trajectories Following Contrasting Prudent and Western Diets from Food Provisions: Robust Biomarkers of Short-Term Changes in Habitual Diet". Nutrients, 11(10), 2407 View Abstract

Wild, J, Shanmuganathan, M, Hayashi, M, Potter, M, and Britz-McKibbin, P, 2019. "Metabolomics for improved treatment monitoring of phenylketonuria: urinary biomarkers for non-invasive assessment of dietary adherence and nutritional deficiencies". Analyst View Abstract

Yamamoto, M, Ines Pinto-Sanchez, M, Bercik, P, and Britz-McKibbin, P, 2019. "Metabolomics reveals elevated urinary excretion of collagen degradation and epithelial cell turnover products in irritable bowel syndrome patients". Metabolomics, 15(82) View Abstract

Shanmuganathan, M and Britz-McKibbin, P, 2019. "New Advances in Amino Acid Profiling in Biological Samples by Capillary Electrophoresis-Mass Spectrometry". View Abstract

Shanmuganathan, M and Britz-McKibbin, P, 2019. "New Advances in Screening of Inborn Errors of Metabolism by Capillary Electrophoresis-Mass Spectrometry". View Abstract

Azab, S, Ly, R, and Britz-McKibbin, P, 2019. "Robust Method for High-Throughput Screening of Fatty Acids by Multisegment Injection-Nonaqueous Capillary Electrophoresis–Mass Spectrometry with Stringent Quality Control". Analytical Chemistry, 91(3), 2329-2336 View Abstract

Cherry, N, Aklilu, Y, Beach, J, Britz-McKibbin, P, Elbourne, R, Galarneau, J, Gill, B, Kinniburgh, D, and Zhang, X, 2019. "Urinary 1-hydroxypyrene and Skin Contamination in Firefighters Deployed to the Fort McMurray Fire". Annals of Work Exposures and Health, 63(4), 448-458 View Abstract

Gill, B, Mell, A, Shanmuganathan, M, Jobst, K, Zhang, X, Kinniburgh, D, Cherry, N, and Britz-McKibbin, P, 2019. "Urinary hydroxypyrene determination for biomonitoring of firefighters deployed at the Fort McMurray wildfire: an inter-laboratory method comparison". Analytical and Bioanalytical Chemistry, 411(7), 1397-1407 View Abstract

2018

DiBattista, A, McIntosh, N, Lamoureux, M, Al-Dirbashi, O, Chakraborty, P, and Britz-McKibbin, P, 2018. "Metabolic Signatures of Cystic Fibrosis Identified in Dried Blood Spots For Newborn Screening Without Carrier Identification". Journal of Proteome Research, 18(3), 841-854 View Abstract

Britz-McKibbin, P, 2018. "Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry for Metabolomics: A Robust Platform for High Throughput Metabolite Profiling with Quality Assurance". View Abstract

Nori de Macedo, A, Mathiaparanam, S, Ly, R, and Britz-McKibbin, P, 2018. "Surveying Iodine Nutrition using Kinetic Spectrophotometry: An Integrative Laboratory Experiment in Analytical Chemistry and Population Health". Journal of Chemical Education, 95, 1029-1034 View Abstract

2017

DiBattista, A, McIntosh, N, Lamoureux, M, Al-Dirbashi, OY, Chakraborty, P, and Britz-McKibbin, P, 2017. "Temporal Signal Pattern Recognition in Mass Spectrometry: A Method for Rapid Identification and Accurate Quantification of Biomarkers for Inborn Errors of Metabolism with Quality Assurance.". Anal Chem, 89(15), 8112-8121 View Abstract

Nori de Macedo, A, Mathiaparanam, S, Brick, L, Keenan, K, Gonska, T, Pedder, L, Hill, S, and Britz-McKibbin, P, 2017. "The Sweat Metabolome of Screen-Positive Cystic Fibrosis Infants: Revealing Mechanisms beyond Impaired Chloride Transport". ACS Central Science View Abstract

De Palma, G, Lynch, MDJ, Lu, J, Dang, VT, Deng, Y, Jury, J, Umeh, G, Miranda, PM, Pigrau Pastor, M, Sidani, S, Pinto-Sanchez, MI, Philip, V, McLean, PG, Hagelsieb, M, Surette, MG, Bergonzelli, GE, Verdu, EF, Britz-McKibbin, P, Neufeld, JD, Collins, SM, and Bercik, P, 2017. "Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice.". Sci Transl Med, 9(379) View Abstract

Nori de Macedo, A, Macri, J, Hudecki, PL, Saoi, M, McQueen, MJ, and Britz-McKibbin, P, 2017. "Validation of a Capillary Electrophoresis Assay for Monitoring Iodine Nutrition in Populations for Prevention of Iodine Deficiency: An Interlaboratory Method Comparison". Journal of Applied Laboratory Medicine, 2(1), 649-660 View Abstract

2016

Jafari, N, Ahmed, R, Gloyd, M, Bloomfield, J, Britz-McKibbin, P, and Melacini, G, 2016. "Allosteric Sensing of Fatty Acid Binding by NMR: Application to Human Serum Albumin.". J Med Chem, 59(16), 7457-65 View Abstract

Fernando, S, Shaw, L, Shaw, D, Gallea, M, VandenEnden, L, House, R, Verma, DK, Britz-McKibbin, P, and McCarry, BE, 2016. "Evaluation of Firefighter Exposure to Wood Smoke during Training Exercises at Burn Houses.". Environ Sci Technol, 50(3), 1536-43 View Abstract

Yamamoto, M, Ly, R, Gill, B, Zhu, Y, Moran-Mirabal, J, and Britz-McKibbin, P, 2016. "Robust and High-Throughput Method for Anionic Metabolite Profiling: Preventing Polyimide Aminolysis and Capillary Breakages under Alkaline Conditions in Capillary Electrophoresis-Mass Spectrometry.". Anal Chem, 88(21), 10710-10719 View Abstract

2015

Wenz, C, Barbas, C, Lopez-Gonzalvez, A, Garcia, A, Benavente, F, Sanz-Nebot, V, Blanc, T, Freckleton, G, Britz-McKibbin, P, Shanmuganathan, M, de l'Escaille, F, Far, J, Haselberg, R, Huang, S, Huhn, C, Pattky, M, Michels, D, Mou, S, Yang, F, Neusuess, C, Tromsdorf, N, Baidoo, EEK, Keasling, JD, and Park, SS, 2015. "Interlaboratory study to evaluate the robustness of capillary electrophoresis-mass spectrometry for peptide mapping.". J Sep Sci View Abstract

Sumner, LW, Styczynski, M, McLean, J, Fiehn, O, Jander, G, Liao, J, Sumner, S, Britz-McKibbin, P, Welti, R, Jones, AD, Dorrestein, PC, Bearden, D, and Kaddurah-Daouk, R, 2015. "Introducing the USA Plant, Algae and Microbial Metabolomics Research Coordination Network (PAMM-NET).". Metabolomics, 11(1), 3-5 View Abstract

Badoud, F, Lam, KP, Perreault, M, Zulyniak, MA, Britz-McKibbin, P, and Mutch, DM, 2015. "Metabolomics Reveals Metabolically Healthy and Unhealthy Obese Individuals Differ in their Response to a Caloric Challenge.". PLoS One, 10(8), e0134613 View Abstract

Kuehnbaum, NL, Gillen, JB, Kormendi, A, Lam, KP, DiBattista, A, Gibala, MJ, and Britz-McKibbin, P, 2015. "Multiplexed separations for biomarker discovery in metabolomics: Elucidating adaptive responses to exercise training.". Electrophoresis View Abstract

2014

de Macedo, AN, Teo, K, Mente, A, McQueen, MJ, Zeidler, J, Poirier, P, Lear, SA, Wielgosz, A, and Britz-McKibbin, P, 2014. "A robust method for iodine status determination in epidemiological studies by capillary electrophoresis.". Anal Chem, 86(20), 10010-5 View Abstract

Kuehnbaum, NL, Gillen, JB, Gibala, MJ, and Britz-McKibbin, P, 2014. "Personalized metabolomics for predicting glucose tolerance changes in sedentary women after high-intensity interval training.". Sci Rep, 4, 6166 View Abstract

Badoud, F, Lam, KP, DiBattista, A, Perreault, M, Zulyniak, MA, Cattrysse, B, Stephenson, S, Britz-McKibbin, P, and Mutch, DM, 2014. "Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese.". J Proteome Res, 13(7), 3455-66 View Abstract

2013

Britz-McKibbin, P, 2013. "Expanded newborn screening of inborn errors of metabolism by capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS).". Methods Mol Biol, 919, 43-56 View Abstract

Shanmuganathan, M and Britz-McKibbin, P, 2013. "High quality drug screening by capillary electrophoresis: a review.". Anal Chim Acta, 773, 24-36 View Abstract

Kuehnbaum, NL, Kormendi, A, and Britz-McKibbin, P, 2013. "Multisegment injection-capillary electrophoresis-mass spectrometry: a high-throughput platform for metabolomics with high data fidelity.". Anal Chem, 85(22), 10664-9 View Abstract

Kuehnbaum, NL and Britz-McKibbin, P, 2013. "New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era.". Chem Rev, 113(4), 2437-68 View Abstract

de Macedo, AN, Jiwa, MIY, Macri, J, Belostotsky, V, Hill, S, and Britz-McKibbin, P, 2013. "Strong anion determination in biological fluids by capillary electrophoresis for clinical diagnostics.". Anal Chem, 85(22), 11112-20 View Abstract

2012

White, CE, Gavina, JMA, Morton, R, Britz-McKibbin, P, and Finan, TM, 2012. "Control of hydroxyproline catabolism in Sinorhizobium meliloti.". Mol Microbiol, 85(6), 1133-47 View Abstract

Shanmuganathan, M and Britz-McKibbin, P, 2012. "Functional screening of pharmacological chaperones via restoration of enzyme activity upon denaturation.". Biochemistry, 51(39), 7651-3 View Abstract

Britz-McKibbin, P, 2012. "New advances in amino acid profiling by capillary electrophoresis-electrospray ionization-mass spectrometry.". Methods Mol Biol, 828, 83-99 View Abstract

2011

Britz-McKibbin, P, 2011. "Capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS)-based metabolomics.". Methods Mol Biol, 708, 229-46 View Abstract

Shanmuganathan, M and Britz-McKibbin, P, 2011. "Inhibitor screening of pharmacological chaperones for lysosomal beta-glucocerebrosidase by capillary electrophoresis.". Anal Bioanal Chem, 399(8), 2843-53 View Abstract

2010

Gavina, JMA, White, CE, Finan, TM, and Britz-McKibbin, P, 2010. "Determination of 4-hydroxyproline-2-epimerase activity by capillary electrophoresis: A stereoselective platform for inhibitor screening of amino acid isomerases.". Electrophoresis, 31(16), 2831-7 View Abstract

Lee, R, West, D, Phillips, SM, and Britz-McKibbin, P, 2010. "Differential metabolomics for quantitative assessment of oxidative stress with strenuous exercise and nutritional intervention: thiol-specific regulation of cellular metabolism with N-acetyl-L-cysteine pretreatment.". Anal Chem, 82(7), 2959-68 View Abstract

Fei, F and Britz-McKibbin, P, 2010. "Direct analysis of polyols using 3-nitrophenylboronic acid in capillary electrophoresis: thermodynamic and electrokinetic principles of molecular recognition.". Anal Bioanal Chem, 398(3), 1349-56 View Abstract

Lee, R and Britz-McKibbin, P, 2010. "Metabolomic studies of radiation-induced apoptosis of human leukocytes by capillary electrophoresis-mass spectrometry and flow cytometry: adaptive cellular responses to ionizing radiation.". Electrophoresis, 31(14), 2328-37 View Abstract

2009

Lee, R and Britz-McKibbin, P, 2009. "Differential rates of glutathione oxidation for assessment of cellular redox status and antioxidant capacity by capillary electrophoresis-mass spectrometry: an elusive biomarker of oxidative stress.". Anal Chem, 81(16), 7047-56 View Abstract

Gavina, JMA, Mazhab-Jafari, MT, Melacini, G, and Britz-McKibbin, P, 2009. "Label-free assay for thermodynamic analysis of protein-ligand interactions: a multivariate strategy for allosteric ligand screening.". Biochemistry, 48(2), 223-5 View Abstract

Chalcraft, KR and Britz-McKibbin, P, 2009. "Newborn screening of inborn errors of metabolism by capillary electrophoresis-electrospray ionization-mass spectrometry: a second-tier method with improved specificity and sensitivity.". Anal Chem, 81(1), 307-14 View Abstract

Chalcraft, KR, Lee, R, Mills, C, and Britz-McKibbin, P, 2009. "Virtual quantification of metabolites by capillary electrophoresis-electrospray ionization-mass spectrometry: predicting ionization efficiency without chemical standards.". Anal Chem, 81(7), 2506-15 View Abstract

2008

Kaiser, C, Segui-Lines, G, D'Amaral, JC, Ptolemy, AS, and Britz-McKibbin, P, 2008. "Electrokinetic probes for single-step screening of polyol stereoisomers: the virtues of ternary boronate ester complex formation.". Chem Commun (Camb)(3), 338-40 View Abstract

Ptolemy, AS and Britz-McKibbin, P, 2008. "New advances in on-line sample preconcentration by capillary electrophoresis using dynamic pH junction.". Analyst, 133(12), 1643-8 View Abstract

2007

Segui-Lines, G, Gavina, JMA, D'Amaral, JC, and Britz-McKibbin, P, 2007. "High-throughput screening of holoprotein conformational stability by dynamic ligand exchange-affinity capillary electrophoresis.". Analyst, 132(8), 741-4 View Abstract

Lee, R, Ptolemy, AS, Niewczas, L, and Britz-McKibbin, P, 2007. "Integrative metabolomics for characterizing unknown low-abundance metabolites by capillary electrophoresis-mass spectrometry with computer simulations.". Anal Chem, 79(2), 403-15 View Abstract

Ptolemy, AS, Lee, R, and Britz-McKibbin, P, 2007. "Strategies for comprehensive analysis of amino acid biomarkers of oxidative stress.". Amino Acids, 33(1), 3-18 View Abstract

2006

Gavina, JMA, Das, R, and Britz-McKibbin, P, 2006. "Dynamic unfolding of a regulatory subunit of cAMP-dependent protein kinase by capillary electrophoresis: Impact of cAMP dissociation on protein stability.". Electrophoresis, 27(21), 4196-204 View Abstract

Samson, S and Britz-McKibbin, P, 2006. "Enhanced binding and conformational selectivity in affinity capillary electrophoresis using a water-soluble resorcin[4]arene as intrinsic buffer and electrokinetic host.". Electrophoresis, 27(4), 842-51 View Abstract

Ptolemy, AS and Britz-McKibbin, P, 2006. "Sample preconcentration with chemical derivatization in capillary electrophoresis. Capillary as preconcentrator, microreactor and chiral selector for high-throughput metabolite screening.". J Chromatogr A, 1106(1-2), 7-18 View Abstract

Ptolemy, AS, Tran, L, and Britz-McKibbin, P, 2006. "Single-step enantioselective amino acid flux analysis by capillary electrophoresis using on-line sample preconcentration with chemical derivatization.". Anal Biochem, 354(2), 192-204 View Abstract

2005

Ptolemy, AS, Le Bihan, M, and Britz-McKibbin, P, 2005. "On-line sample preconcentration with chemical derivatization of bacterial biomarkers by capillary electrophoresis: a dual strategy for integrating sample pretreatment with chemical analysis.". Electrophoresis, 26(21), 4206-14 View Abstract

Ptolemy, AS and Britz-McKibbin, P, 2005. "Single-step analysis of low abundance phosphoamino acids via on-line sample preconcentration with chemical derivatization by capillary electrophoresis.". Analyst, 130(9), 1263-70 View Abstract

2003

Britz-McKibbin, P, Ichihashi, T, Tsubota, K, Chen, DDY, and Terabe, S, 2003. "Complementary on-line preconcentration strategies for steroids by capillary electrophoresis.". J Chromatogr A, 1013(1-2), 65-76 View Abstract

Markuszewski, MJ, Britz-McKibbin, P, Terabe, S, Matsuda, K, and Nishioka, T, 2003. "Determination of pyridine and adenine nucleotide metabolites in Bacillus subtilis cell extract by sweeping borate complexation capillary electrophoresis.". J Chromatogr A, 989(2), 293-301 View Abstract

Kim, J, Britz-McKibbin, P, Hirokawa, T, and Terabe, S, 2003. "Mechanistic study on analyte focusing by dynamic pH junction in capillary electrophoresis using computer simulation.". Anal Chem, 75(16), 3986-93 View Abstract

Britz-McKibbin, P and Terabe, S, 2003. "On-line preconcentration strategies for trace analysis of metabolites by capillary electrophoresis.". J Chromatogr A, 1000(1-2), 917-34 View Abstract

Britz-McKibbin, P, Markuszewski, MJ, Iyanagi, T, Matsuda, K, Nishioka, T, and Terabe, S, 2003. "Picomolar analysis of flavins in biological samples by dynamic pH junction-sweeping capillary electrophoresis with laser-induced fluorescence detection.". Anal Biochem, 313(1), 89-96 View Abstract

Britz-Mckibbin, P, Nishioka, T, and Terabe, S, 2003. "Sensitive and high-throughput analyses of purine metabolites by dynamic pH junction multiplexed capillary electrophoresis: a new tool for metabolomic studies.". Anal Sci, 19(1), 99-104 View Abstract

2002

Britz-McKibbin, P and Chen, DDY, 2002. "Accurately describing weak analyte-additive interactions by capillary electrophoresis.". Electrophoresis, 23(6), 880-8 View Abstract

Britz-McKibbin, P and Terabe, S, 2002. "High-sensitivity analyses of metabolites in biological samples by capillary electrophoresis using dynamic pH junction-sweeping.". Chem Rec, 2(6), 397-404 View Abstract

Britz-McKibbin, P, Otsuka, K, and Terabe, S, 2002. "On-line focusing of flavin derivatives using Dynamic pH junction-sweeping capillary electrophoresis with laser-induced fluorescence detection.". Anal Chem, 74(15), 3736-43 View Abstract

2000

Britz-McKibbin, P and Chen, DD, 2000. "Selective focusing of catecholamines and weakly acidic compounds by capillary electrophoresis using a dynamic pH junction.". Anal Chem, 72(6), 1242-52 View Abstract

Britz-McKibbin, P, Bebault, GM, and Chen, DD, 2000. "Velocity-difference induced focusing of nucleotides in capillary electrophoresis with a dynamic pH junction.". Anal Chem, 72(8), 1729-35 View Abstract

1999

Britz-Mckibbin, P, Wong, J, and Chen, DD, 1999. "Analysis of epinephrine from fifteen different dental anesthetic formulations by capillary electrophoresis.". J Chromatogr A, 853(1-2), 535-40 View Abstract

Britz-Mckibbin, P, Vo, HC, MacGillivray, RT, and Chen, DD, 1999. "Analysis of gamma-carboxyglutamic acid content of protein, urine, and plasma by capillary electrophoresis and laser-induced fluorescence.". Anal Chem, 71(8), 1633-7 View Abstract

Vo, HC, Britz-Mckibbin, P, Chen, DD, and MacGillivray, RT, 1999. "Undercarboxylation of recombinant prothrombin revealed by analysis of gamma-carboxyglutamic acid using capillary electrophoresis and laser-induced fluorescence.". FEBS Lett, 445(2-3), 256-60 View Abstract

1998

Britz-McKibbin, P and Chen, DD, 1998. "A water-soluble tetraethylsulfonate derivative of 2-methylresorcinarene as an additive for capillary electrophoresis.". Anal Chem, 70(5), 907-12 View Abstract

Britz-Mckibbin, P, Kranack, AR, Paprica, A, and Chen, DD, 1998. "Quantitative assay for epinephrine in dental anesthetic solutions by capillary electrophoresis.". Analyst, 123(7), 1461-3 View Abstract

Kranack, AR, Bowser, MT, Britz-McKibbin, P, and Chen, DD, 1998. "The effects of a mixture of charged and neutral additives on analyte migration behavior in capillary electrophoresis.". Electrophoresis, 19(3), 388-96 View Abstract

1997

Peng, X, Bowser, MT, Britz-McKibbin, P, Bebault, GM, Morris, JR, and Chen, DD, 1997. "Quantitative description of analyte migration behavior based on dynamic complexation in capillary electrophoresis with one or more additives.". Electrophoresis, 18(5), 706-16 View Abstract

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