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Meera Shanmuganathan, Zachary Kroezen, Sabrina Macklai, and Philip Britz-McKibbin (2019)

Comprehensive Surveillance of Drugs of Abuse

GIT Laboratory Journal.

Chronic pain have fuelled an opioid crisis in North America. Due to the high risk of dependence and intoxication, there exists an urgent need for a rapid and low-cost analytical method to reliably screen for opioids and other drugs of abuse (DoA). This information is critical for the therapeutic monitoring of high-risk patients at methadone clinics and pain management centres. Here, we present a high-throughput method (<3 min/sample) for comprehensive surveillance of narcotic drugs and their metabolites above their recommended screening cut-off concentrations in urine when using multi-segment injection-capillary electrophoresis-mass spectrometry (MSI-CE-MS).

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