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Expanding Lipidomic Coverage

Check out Ritchie's newest publication in Analytical Chemistry from his PhD work. Here he explores a novel derivatization protocol for lipids based on 3-methyl-1-p-tolyltriazene (MTT) as a safer alternative to diazomethane for quantitative phospholipid (PL) methylation. This charge-switch derivatization strategy expanded his lipidome coverage when using MSI-NACE-MS under positive ion mode with improved resolution, greater sensitivity, and higher throughput.

Expanding Lipidomic Coverage in Multisegment Injection–Nonaqueous Capillary Electrophoresis–Mass Spectrometry via a Convenient and Quantitative Methylation Strategy